76 results
Idiopathic Inflammatory Myopathies - 
Dermatomyositis (DM), Immune-Mediated Necrotizing Myopathy (IMNM), Antisynthetase Syndrome (ASS), Inclusion Body Myositis
Idiopathic Inflammatory Myopathies ... Immune-Mediated Necrotizing Myopathy ... Antisynthetase Syndrome ... #Idiopathic #Myopathy ... #Comparison #Managment
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
• Inflammatory myopathy ... hypothyroid-induced myopathy ... Statin-induced myopathy ... - Necrotizing myopathy ... #diagnosis #management
Idiopathic Inflammatory Myopathies (IIM's)

RASH + MUSCLE WEAKNESS → Consider idiopathic inflammatory myopathies (IIM's)

 • Overlap Myositis
Idiopathic Inflammatory Myopathies ... Any inflammatory myopathy ... antisynthetase syndrome ... Inflammatory myopathy ... #dermatology #Myopathy
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Myositis Necrotizing myopathy ... anti-synthetase syndrome ... and anti-HMGCR myopathy
What is a Boxer’s fracture?? Fracture of the 4th or 5th metacarpal neck
 - Common in
What is a Boxer’s fracture ... Fracture of the ... – compartment syndrome ... Management: - ... Metacarpal #Diagnosis #Management
Scaphoid Fractures
The scaphoid is the most commonly fractured carpal bone. Remember, if a fracture is suspected
Scaphoid Fractures ... most commonly fractured ... dislocation • ED Management ... Wrist #Carpal #Radiology ... XRay #Diagnosis #Management
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
• Acute stroke syndromes ... Paraneoplastic syndrome ... Lambert-Eaton - Isaacs' syndrome ... proximal weakness Myopathy ... mediated necrotizing myopathy
Important Causes of Diplopia 
TIER 1-CRITICAL
Basilar artery thrombosis, Botulism, Basilar meningitis, Aneurysmn
TIER 2-EMERGENT:
Vertebral dissection, Myasthenia gravis,
, Orbital apex syndrome ... Miller-Fisher syndrome ... sclerosis, Thyroid myopathy
Triquetral Fracture
The triquetrum is the second most commonly fractured carpal bone. Look for the "pooping duck
Triquetral Fracture ... most commonly fractured ... • ED Management ... Wrist #Carpal #Radiology ... XRay #Diagnosis #Management
Myositis Specific Antibodies (MSAs)

Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE
Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ
Immune Mediated
Anti-Synthetase Syndrome ... Mediated Necrotizing Myopathy