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Myositis and Myopathies #ESR #CK #Differential diagnosis of myopathy #Inflammatory #myopathies #Dermatomyositis #muscle weakness #Polymyositis #Inclusion body myositis #Polymyalgia rheumatica #Fibromyalgia #Hypothyroid myopathy #Muscle stiffness #Drug-induced
Myositis and Myopathies ... #ESR #CK #Differential ... #Inflammatory #myopathies ... Dermatomyositis #muscle ... #Drug-induced myopathies
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
Myositis and Myopathies ... weakness • Elevated CK ... rash • Elevated CK ... mildly elevated CK ... BostonChiefs #Myositis #Myopathies
Creatine Kinase - Causes of Elevated CK Levels Acute CK Elevation (Pain > Weakness): • RHABDOMYOLYSIS
Causes of Elevated CK ... Levels Acute CK ... ): • PROXIMAL MUSCLE ... - Metabolic Myopathies ... Kinase #Elevated #CK
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Inflammatory Myopathies ... , drug-induced myopathies ... Tests: • Measure CK ... (symmetric) • CK ... weakness • CK
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
Statin Induced Muscle ... Statin-Associated Muscle ... • The onset of muscle ... → Inflammatory myopathies ... Diagnosis: • CK
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
Inflammatory Myopathies ... : Proximal • CK ... : Proximal • CK ... : Proximal • CK ... #Inflammatory #Myopathies
RHABDOMYOLYSIS • Characterized by skeletal muscle breakdown & necrosis. • Elevated Creatine kinase (CK) hallmark of rhabdomyolysis. • Defined based
Characterized by skeletal muscle ... Creatine kinase (CK ... Defined based on CK ... • Half-life of CK ... useful marker of muscle
Creatine kinase (CK) is an intracellular enzyme present in skeletal muscle, myocardium & brain; smaller amounts
Creatine kinase (CK ... present in skeletal muscle ... of underlying muscle ... CK may increase ... useful marker of muscle
Usmle step 2 ck Pulmonary diseases (High yield points) #usmle #algorithm
Usmle step 2 ck ... yield points) #usmle
Dysphagia - Differential Diagnosis Algorithm Oropharyngeal Dysphagia Esophageal Dysphagia • Upper 2/3 (striated muscle): stroke, NMJ
2/3 (striated muscle ... Lower 2/3 (smooth muscle ... . inflammatory myopathies
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