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myopathies sle associations champs classification complement connectivetissuediseases ctild defects druginduced erythematosus hypocomplementemia ild inflammatory inherited lungdisease management mnemonic monoclonal myopathy
Connective tissue disease-associated interstitial lung diseases LIP: lymphoid interstitial pneumonia. NSIP: nonspecific interstitial pneumonia. OP: organizing pneumonia.
SLE : systemic lupus ... LungDisease #CTILD #Diagnosis ... #Differential # ... Comparison #Table ... #Pulmonary #Rheumatology
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
S - Systemic Lupus ... Hypocomplementemia #Low ... CHAMPS #Mnemonic #diagnosis ... #differential # ... hematology
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
Body Myositis • Slow ... uncommon 5-15% of lupus ... Myopathies #myopathy #differential ... #diagnosis #comparison ... #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
in >90% - Low ... 60-80% - Low ... #sle #comparison ... #table #rheumatology ... #diagnosis #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low ... permanent alopecia Differential ... Non-autoimmune rheumatologic ... , lymphopenia, low ... #Rheumatology
Inherited Qualitative Platelet Defects Bernard-Soulier Syndrome • Defect of adhesion due to a lack of GP Ib/IX/V
in non-muscle myosin ... cataracts, and renal ... Platelet #Defects #comparison ... #table #differential ... #diagnosis #hematology
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
Onset: Insidious/slow ... Inflammatory #Myopathies #differential ... #diagnosis #comparison ... #rheumatology # ... table
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
to cold IgG • Lupus ... , retinal, DVT, ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Diagnosis Framework ... inflammation Others: • Lupus ... such as systemic lupus ... • Complement (Low ... #diagnosis #rheumatology
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