15 results
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
association • M > F Clinical ... Oral aphthae : SLE ... • Arthritis: SLE ... Syndrome #diagnosis #management ... signs #symptoms #rheumatology
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Clinical triad ... Complications: MAS ... • Ocular: uveitis ... #diagnosis #management ... #treatment #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... Erythematous, macular ... Non-autoimmune rheumatologic ... lymphoproliferative syndrome Clinical ... Chronic B-cell activation
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
, such as SLE, atherosclerotic ... , and ocular inflammation ... Cogan syndrome: Ocular ... disease #Vasculitis ... Differential #Diagnosis #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Activation of CD8 ... : SLE+++, Adult-onset ... Still disease, ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation ... Fever is the main clinical ... erythematosus [SLE ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
malignancies, vasculitis ... Cryofibrinogenemia Clinical ... pulmonary emboli, and ocular ... Diagnosis: • + Clinical ... Cryofibrinogenemia #diagnosis #rheumatology
Oroya Fever
Hematologic disease caused by Bartonella bacilliformis
Restricted to the Andes highlands of Peru & Ecuador
B. bacilliformis:
Fever Hematologic disease ... Lutzomyia verrucarum Clinical ... jaundice ​• Neuro: AMS ... Clinical Presentation ... Fever #diagnosis #management
IgG4-Related Disease
Clinical history:  Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
 •
Clinical history ... : Man, 60 years ... No necrosis, No vasculitis ... #diagnosis #management ... workup #treatment #rheumatology
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... gland) biopsy • Ocular ... salivary ducts Clinical ... Sjogrens #Syndrome #Rheumatology ... #Diagnosis #Management