9 results
Features of a Sickle Cell Crisis 
Sickle-cell disease - an autosomal recessive blood disorder.
Characterized by red
Crisis Sickle-cell ... These cells can ... 2) Aplasia - Acute ... #Features #Signs ... #Symptoms
Acute Rheumatic Fever: Pathogenesis and Clinical Findings

Delayed autoimmune reaction
-> Molecular mimicry
-> GAS antigen cross-reacts with host
->
Acute Rheumatic ... -> GAS antigen cross-reacts ... B and CD-4+ T cells ... pathophysiology #diagnosis #signs ... #symptoms #complications
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
with no early symptoms ... Physical Exam/Signs ... ’s lymphoma or acute ... Contamination, colitis ... workup #oncology #hematology
Clinical Manifestations of Sickle Cell Disease

Anaemia
Infection
Painful crises
Priapism
Splenomegaly
Long Term Problems - Short stature and delayed puberty, Stroke
Manifestations of Sickle Cell ... Infection Painful crises ... Splenomegaly Long Term ... SickleCell #Disease #Signs ... #Symptoms #Diagnosis
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
polymorphisms alter cell-mediated ... various inflammatory cells ... histopathologic term ... Pathophysiology #Diagnosis #Signs ... #Symptoms
Mastoiditis: Pathogenesis and clinical findings

Acute or Chronic Otitis Media -> 
Stage 1: Hyperemeia of the mastoid
clinical findings Acute ... ) Stage 4: Cell ... larger & irregular cavities ... pathophysiology #signs ... #symptoms #diagnosis
Central Retinal Artery Occlusion: Pathogenesis and clinical findings
 • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
anti-coagulation • Hematologic ... trucking" • Acute ... Retina • Ganglion cells ... ophthalmology #diagnosis #signs ... #symptoms
Avascular Necrosis: Pathogenesis and Clinical Findings
 • Physical Trauma (esp. to the scaphoid bone with damage
disease (sickle crisis ... affected) - Acute ... hypolucency "Crescent sign ... pathophysiology #diagnosis #signs ... #symptoms
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Presentation: Systemic Symptoms ... purpura: Strong sign ... CRP GCA (Giant Cell ... Multinucleated giant cells ... • Progressive symptoms