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diagnosis management symptoms syndrome workup arteritis autoinflammatory behcet chronic cll colitis derm differential e1 erythematosus gangrenosum gca giantcell igg4 leukemia
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
Somatic) Syndrome Clinical ... thromboembolic disease ... recurrent fevers, vasculitis ... NEJM Review: https ... Autoinflammatory #Somatic #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... Butterfly rash, Vasculitis ... pain (20%) Renal disease ... erythematosus #signs ... symptoms #diagnosis #rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
association • M > F Clinical ... Behcet syndrome (Clinical ... , ulcerative colitis ... diagnosis #management #signs ... #symptoms #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
atherosclerotic disease ... purpura: Strong sign ... Multinucleated giant cells ... pulmonary infiltrates/cavities ... Differential #Diagnosis #Rheumatology
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
IgG4-Related Disease ... Clinical history ... No necrosis, No vasculitis ... supporting long-term ... workup #treatment #rheumatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... Physical Exam/Signs ... can indicate disease ... Contamination, colitis ... workup #oncology #hematology
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
systemic inflammatory vasculitis ... Diagnosis = clinical ... systemic sx + signs ... them, but urgent rheumatology ... GCA #Temporal #Signs
Pyoderma Gangrenosum in Ulcerative Colitis- ...left chest (Panel A) and leg (Panel B). The physical examination
leukocytoclastic vasculitis ... inflammatory bowel disease ... #clinical #photo ... #NEJM #pyoderma ... #derm
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