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diagnosis differential rheumatology agglutinin algorithm anemia autoimmune betadglucan classification cold disease falsepositives fungal galactomannan hemolysis hemolytic hepatitis hepatology injury laboratory
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Drug-associated, PCH ... Liver Disease, PNH ... Laboratory Tests ... Differential #Diagnosis #hematology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
HBV, HCV, HEV, EBV ... , PSC, IgG4, HLH ... stone, Malignancy, PBC ... extrahepatic source - Tests ... diagnosis #algorithm #hepatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
- Mycoplasma, EBV ... Hemoglobinuria (PCH ... • Diagnostic Test ... Donath-Landsteiner test ... hemolytic #anemia #hematology
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
Other +s: PCP, Histo ... IA PPV NPV ... the use of this test ... in pts with GIT mucositis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
glomerulonephritis) • Anti-GBM ... Conjunctivitis, mucositis ... retinopathy Lab Tests ... differential #diagnosis #rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis ... Diagnostic Tests ... • ANA < 20 % IBM ... Other Diseases: • PBC ... #Myopathy #rheumatology
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