22 results
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
that disrupts immune ... accumulation of clinical ... Assessment • Clinical ... Drugs, Unknown cause ... Lymphohistiocytosis #diagnosis #management
IDSA Algorithm for the Management of Purulent skin and soft tissue infections (SSTIs). 
Mild infection: for
Algorithm for the Management ... 12 000 or <400 cells ... or those with clinical ... including those caused ... SSTIs #Algorithm #Management
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
mutations) • Immune ... Aplastic Anemia Clinical ... and petechiae Causes ... Sulfonamides - NSAIDs ... hematology #diagnosis #management
Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings

Medical Comorbidities Malignancies (most commonly hairy-cell leukemia)
Immunogenetic Predisposition: patient is
Pathogenesis and Clinical ... a dysregulated immune ... Environmental triggers - Infectious ... Viral replication causes ... Pathophysiology #Diagnosis #Signs
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
Pathogenesis and Clinical ... Findings - Infectious ... respiratory tract infections ... cell-mediated immune ... Pathophysiology #Diagnosis #Signs
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
activation of an immune ... Transverse Myelitis - Clinical ... • Bilateral signs ... causes need to ... Myelitis #diagnosis #management
CNS Infection in HIV / AIDS - Differential Diagnosis Framework

Principles of HIV-Associated CNS Opportunistic Infections:
 •
less than 200 cells ... should be based on clinical ... required until immune ... Demyelinating disease caused ... InfectiousDiseases #Neurology
Amyotrophic Lateral Sclerosis (ALS) Summary
ALS: combination of the clinical examination finding of amyotrophy with the pathologic
combination of the clinical ... are the immune ... - Causes progressive ... Lateral #Sclerosis #neurology ... #diagnosis #management
Guillain-Barré Syndrome (GBS)
Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness
Epidemiology:
 • Incidence: 1
Incidence: 1 to 2 cases ... transplantation CLINICAL ... specific therapy, the clinician ... Syndrome #diagnosis #management ... #neurology
Myasthenia Gravis Overview

Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction.  Ab to
- Peek sign ... : Steroids and NSAIDs ... precipitated by: Drugs, infection ... Gravis #diagnosis #management ... #neurology