Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings Medical Comorbidities Malignancies (most commonly hairy-cell leukemia) Immunogenetic Predisposition: patient is genetically predisposed to a dysregulated immune response Environmental triggers - Infectious/viral agents (commonly Hepatitis B) - Postulate 1 - Viral antigen-antibody complexes deposit in vasculature, causing lesions and activating cellular inflammatory response - Postulate 2 - Viral replication causes direct injury to vascular endothelial cells - Palpable or necrotic purpura - Malignant Hypertension - Renal Insufficiency - Myocardial ischemia - Heart failure - Diffuse myalgias - Orchitis: Testicular pain, erythema and/or swelling - GI Manifestations: Non-specific abdo pain, GI hemorrhage, Small intestine perforation - Peripheral sensory changes: Distal mononeuropathy multiplex #PAN #PolyarteritisNodosa #Pathophysiology #Diagnosis #Signs #Symptoms #Vasculitis
