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differential hematology management oncology classification vasculitis algorithm alopecia anemia anorexianervosa aplastic arteritis bronchiectasis common complications disorders distribution eosinophil gca giantcell
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
(common causes ... organ-specific signs ... or symptoms (eg ... #Differential #diagnosis ... #hematology #eosinophilia
Allopecia - Differential Diagnosis Framework for Hair Loss Localized / Focal Hair Loss Pattern: • Scarring Alopecia:
- Differential Diagnosis ... Alopecia areata (+Nail ... Examination: • Signs ... skin surface, nails ... #dermatology #Hairloss
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... Dehydration • Symptoms ... WBC >100k, + lab signs ... Syndrome #TLS #diagnosis ... #management #hematology
Bronchiectasis - Summary What? • Bronchiectasis is derived from the Greek words bronckos meaning airway and ectasis meaning
inflammation Symptoms ... • Clubbing of nails ... Nasal polyps and signs ... parenchyma Diagnosis ... #differential #diagnosis
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
those coming off aorta ... systemic sx + signs ... them, but urgent rheumatology ... GCA #Temporal #Signs ... #Symptoms #Diagnosis
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
purpura: Strong sign ... < 30 years • Aorta ... Arteritis): • Aorta ... tract, and often causes ... #Rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
rapid onset of symptoms ... -> AML: Blast crises ... • (Peripheral eosinophilia ... #Leukemia #Hematology ... #Oncology #Diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
• EGPA: - Eosinophilia ... tract, and often causes ... Presentation - Systemic Symptoms ... purpura: strong sign ... #rheumatology #
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... - Hepatitis, eosinophilic ... • Improve the symptoms ... Anemia #oncology #hematology ... #diagnosis #management
When to look for clonal/neoplastic hypereosinophilia (HEo)? - Exclusion of frequent causes (Drug-induced HEo, helminthiasis, cancer,
Exclusion of frequent causes ... ) - Clinical symptoms ... hypereosinophilia #HEON #Diagnosis ... #Signs #Hematology
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