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dermatology rheumatology oncology skin syndrome arthritis chronic cll differential leukemia lupus lymphocytic pathophysiology sle summary treatment activation agglutinin bacilliformis bandemia
Gastrointestinal Evaluation of Iron Deficiency Anemia In patients with anemia, diagnose iron deficiency if: • Ferritin <
, diagnose iron ... Test for celiac disease ... endoscopy only if: • Negative ... change medical management ... Gastrointestinal #Evaluation #workup
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
40, F:M 9:1 • Clinical ... • Immunologic Workup ... pANCA anti-MPO - Negative ... Evolution: Chronic disease ... #rheumatology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
hallmark for the disease ... result in severe anemia ... antiglobulin tests - Negative ... immune hemolytic anemia ... #Workup #Hematology
Oroya Fever Hematologic disease caused by Bartonella bacilliformis Restricted to the Andes highlands of Peru & Ecuador B. bacilliformis:
Oroya Fever Hematologic ... disease caused ... bacilliformis: - Gram negative ... severe hemolytic anemia ... #management #Bartonella
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Viral Infection Clinical ... • Symptoms of anemia ... anemia • Cold ... for anti-C3d and negative ... #hematology #diagnosis
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
IgG4-Related Disease ... Clinical history ... • Some false negative ... #diagnosis #management ... #phenotypes #workup
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Normal: < 1% Clinically ... • Autoimmune diseases ... likelihood of negative ... clinical outcomes ... neutrophil #WBC #CBC #hematology
Septic Arthritis - Diagnosis and Management Summary Clinical Exam: hot, swollen, pain with passive AND active ROM
and Management ... Summary Clinical ... necrosis, Lyme disease ... viral arthritis Workup ... staphylococcus, gram negative
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to 8 years Clinical ... autoimmune hemolytic anemia ... and M panel Management ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... • Immunologic Workup ... pANCA anti-MPO - Negative ... Evolution: Chronic disease ... #diagnosis #management
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