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hepatitis lfts obstetrics pregnancy transaminitis aclf algorithm biliary chemistry cholangitis chronic comparison disease failure fatty gap globulin hellp icp interpretation
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... those with CLD (± cirrhosis ... Injury (DILI) ... #Hepatology #gastroenterology ... #management #diagnosis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential ... Diagnosis Algorithm ... hepatitis: < 1 • Cirrhosis ... #hepatology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... of Pregnancy (AFLP ... (DIC, ascites, jaundice ... infiltration) Differential ... Pregnancy #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
• Near normal ... hepatitis: < 1 • Cirrhosis ... #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
- Acute Viral Hepatitis ... CMV), Alcoholic cirrhosis ... #Injury #hepatology ... transaminitis #differential ... #diagnosis
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
Pruritus, Mild jaundice ... and hemorrhage Acute ... Disease #Pregnancy #hepatology ... hepatitis #comparison #differential ... #diagnosis #icp
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
/Liver failure ... hyperpigmentation • Jaundice ... obstruction • ALP ... bile ducts Differential ... #workup #hepatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Sarcoidosis) • Liver ... disease: Cirrhosis ... gastric tumors • Hematology ... Gap #ProteinGap #differential ... #diagnosis #hematology
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