11 results
Evidence for Epinephrine in OHCA.  ROSC != Neuro Intact Survival 
#EBM #Prehospital #Epinephrine #ROSC #OHCA
Epinephrine in OHCA ... Epinephrine #ROSC #OHCA ... #ACLS #NeuroIntact
Type IV Hypersensitivity: Pathogenesis and clinical findings
Definition: Unique because it is entirely T-Cell mediated; exposure to
mediated; exposure to allergen ... development of allergen-specific ... Allergic reaction ... because T-Cell activation ... Initial exposure to allergen
In July 2015 the ACC/AHA proposed and published an algorithm to help stratify cardiac arrest patients
emergent cath lab activation ... CardiacArrest #Algorithm #OHCA ... CathLab #NSTEMI #Activation
Table 1 – Studies evaluating epinephrine - The Bottom Line: Epinephrine can increase ROSC, but it
Epinephrine #ROSC #OHCA ... #ACLS #NeuroIntact
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
Soluble antigen - Allergen-specific ... When the specific allergen ... to complement activation ... Complement activation ... Pathophysiology #Allergy
Asthma: immunopathogenesis. 
Allergens attach to, and are taken up by, dendritic cells that he the respiratory
interaction of the allergen ... mucus production allergic ... PAF, platelet-activating
Hypersensitivity: Definitions
 • Type I - Production of lgE Abs that bind to harmless allergens and
leading to an allergic ... leading to an allergic ... An allergic reaction ... because T-Cell activation ... #Allergic #Reactions
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Mechanism of Action: Allergen-specific ... to complement activation ... reactions #types #allergy
Antiplatelet Medications - Summary Table

Aspirin - Inhibits cyclooxygenase, preventing formation of thromboxane A2
 • Acute coronary
preventing platelet activation ... aspirin in aspirin-allergic
Kounis Syndrome

Acute coronary syndrome (symptoms such as chest pain relating to reduced blood flow to the
) caused by an allergic ... Mast cell activation ... Kounis #Syndrome #Allergic