12 results
Hypernatremia - Differential Diagnosis Workup Algorithm

1) Check Urine Osmolality:
 > 600 mOsm/kg - Implies extrarenal mechanism
• Hypovolemic: Diuretics ... osmotic (solute) diuresis ... Hypervolemic: Conn syndrome ... , Cushing syndrome ... Algorithm #nephrology #sodium
Modified Hyponatremia Algorithm
Hypertonic Hyponatremia: Hyperglycemia, Mannitol, Urologic irrigants
Hypotonic Hyponatremia: 
 • ADH ON (UOsm > 100):
: • ADH ON (UOsm ... Cirrhosis, Nephrotic syndrome ... , Medications (diuretics ... salt wasting • ADH ... Algorithm #diagnosis #sodium
Physiologic Approach to Hypotonic Hyponatremia
The next time you have a case of hypotonic hyponatremia, give the
Approach to Hypotonic Hyponatremia ... : SIADH, Renal Sodium ... loss (diuretics ... Cirrhosis, Nephrotic syndrome ... diagnosis #table #sodium
Hyponatremia - Diagnosis and Treatment
Hyponatremia is usually caused by the inability to excrete water normally.
majority of cases, ADH ... 2) Is ADH elevated ... demyelination syndrome ... of symptomatic (seizures ... management #nephrology #sodium
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
disequilibrium syndrome ... • Hyponatremia ... • Nephrogenic ... Tolvaptan) • Treatment ... and euvolemic hyponatremia
Hyponatremia (<135 mEq/L) is a common electrolyte abnormality caused by an excess of total body water
Hyponatremia (<135 ... asymptomatic to seizures ... True hyponatremia ... release of anti-diuretic ... #hyponatremia #ADH
Hypernatremia - Differential Diagnosis and Treatment
Hypernatremia is almost always due to unreplaced water loss (free water
Hypernatremia - ... unavailable 2) Osmotic Diuresis ... Diabetes Insipidus: neurogenic ... , nephrogenic 4 ... management #nephrology #sodium
Management of Hyponatremia
Hypertonic Saline - Only indicated if patient has severe symptoms + Na < 125
Give
Management of Hyponatremia ... Diuretics ... Add Diuretics, Consider ... give specific treatment ... #sodium
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
- Compartment syndrome ... exertion/training - Seizures ... Aldolase ↑ • LDH ... Hyperuricemia • Hyponatremia ... Loop diuretics for
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
thiazide-sensitive sodium ... thiazide-sensitive sodium ... with thiazide diuretic ... tachycardia • Seizures ... Rhabdomyolysis Treatment