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nephrology diagnosis differential treatment causes hyponatremia pathophysiology pharmacology algorithm correction diuresis diuretics excretion gitelman goal heat heatstroke hypokalemia illness mechanism
Hypernatremia - Differential Diagnosis Workup Algorithm 1) Check Urine Osmolality: > 600 mOsm/kg - Implies extrarenal mechanism
Hypernatremia - ... insipidus (central or nephrogenic ... Hypervolemic: Conn syndrome ... , Cushing syndrome ... Algorithm #nephrology #sodium
Anticonvulsants as Mood Stabilizers: Mechanism and Side-effect Examples: Valproate, Carbamazepine, Lamotrigine • Mild anticholinergic effect -> Drowsiness
Anticonvulsants ... Stevens-Johnson Syndrome ... -> Withdrawal seizure ... vomiting, diarrhea, hyponatremia ... thrombocytopenia #Anticonvulsants
Hypernatremia - Differential Diagnosis and Treatment Hypernatremia is almost always due to unreplaced water loss (free water
Hypernatremia - ... Diabetes Insipidus: neurogenic ... , nephrogenic 4 ... Diagnosis #Treatment #management ... #nephrology #sodium
Hyponatremia Correction 1. Indications for Hypertonic Saline: seizure, coma, focal findings - typically occurs with
Hyponatremia Correction ... Hypertonic Saline: seizure ... Overcorrection of Hyponatremia ... Demyelination Syndrome ... Correction #goal #rate #management
Hyponatremia - Diagnosis and Treatment Hyponatremia is usually caused by the inability to excrete water normally.
Hyponatremia - Diagnosis ... demyelination syndrome ... of symptomatic (seizures ... Diagnosis #Treatment #management ... #nephrology #sodium
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
disequilibrium syndrome ... irrigation • Management ... • Hyponatremia ... • Nephrogenic ... and euvolemic hyponatremia
Heat Illnesses and Heat Stroke - Differential Diagnosis Framework Heat Cramps: • Muscle pain or spasm -
Dehydration - Loss of sodium ... conditions - Neurogenic ... heat illness → Hypernatremia ... consciousness, Coma/seizure
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Framework and Management ... - Compartment syndrome ... exertion/training - Seizures ... Hyperuricemia • Hyponatremia ... Differential #Diagnosis #Management
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
Gitelman Syndrome ... thiazide-sensitive sodium ... thiazide-sensitive sodium ... tachycardia • Seizures ... diagnosis #nephrology #management
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