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diagnosis differential hyponatremia causes alkalosis gitelman hypokalemia hypotonic management metabolic neurology pathophysiology physiologic table urinary urine volume workup
Hypernatremia - Differential Diagnosis Workup Algorithm 1) Check Urine Osmolality: > 600 mOsm/kg - Implies extrarenal mechanism
Diagnosis Workup Algorithm ... • Euvolemic (Low ... Hypervolemic: Conn syndrome ... , Cushing syndrome ... #nephrology #sodium
Modified Hyponatremia Algorithm Hypertonic Hyponatremia: Hyperglycemia, Mannitol, Urologic irrigants Hypotonic Hyponatremia: • ADH ON (UOsm > 100):
Algorithm Hypertonic ... Cirrhosis, Nephrotic syndrome ... Primary polydipsia, Low ... #Algorithm #diagnosis ... #sodium #nephrology
Causes of Seizures - Differential Diagnosis Algorithm Unprovoked - Epilepsy: • Focal: Simple, Complex • Generalized: Absence,
Causes of Seizures ... vasoconstriction syndrome ... Traumatic brain injury ... Hyperglycemia, Hyponatremia ... #Causes #neurology
Volume Based Approach to Hyponatremia Hypovolemic, Serum uric acid >4 • Urine Na <20: Extra-renal losses •
Based Approach to Hyponatremia ... Hypothyroidism, Low ... Cirrhosis, Nephrotic syndrome ... #algorithm #diagnosis ... #sodium #low #nephrology
Metabolic Alkalosis - Urinary Chloride Algorithm Cl- responsive metabolic alkalosis • Kidney loss of Cl-
Algorithm Cl- ... alkalosis • Normal/low ... , Gitelman syndrome ... #urine #Algorithm ... #nephrology #differential
Physiologic Approach to Hypotonic Hyponatremia The next time you have a case of hypotonic hyponatremia, give the
normal volume-based algorithm ... : SIADH, Renal Sodium ... can be high or low ... Cirrhosis, Nephrotic syndrome ... #nephrology
Hyponatremia - Differential Algorithm Isotonic Hyponatremia: Hyperlipidemia, Hyperproteinemia, Recent TURP Hypotonic Hyponatremia: • Hypovolemia: Diuretics/Nephropathies, Vomiting, Diarrhea,
Algorithm Isotonic ... Cirrhosis, Nephrotic Syndrome ... #Differential #Algorithm ... diagnosis #causes #nephrology ... #sodium #low
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
thiazide-sensitive sodium ... thiazide-sensitive sodium ... alkalosis • Normal or low ... tachycardia • Seizures ... #diagnosis #nephrology
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