9 results
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Syndrome in APML ... Diagnosis: >3 symptoms ... #Syndrome #APML ... #diagnosis #management ... #hematology #oncology
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... microscopy and serial ... context of other symptoms ... #patterns #rheumatology ... #diagnosis #differential
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
- Differential ... Thrombosis and arterial ... Presentation - Systemic Symptoms ... C-ANCA) pattern: antibodies ... #rheumatology #
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
ab • RF • Antinuclear ... ) • Cutaneous vasculitis ... : 2% Systemic Vasculitis ... #Rheumatology # ... Diagnosis #Management
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
) Differential Diagnosis ... Nonsurgical abdominal pain ... #diagnosis #management ... #signs #symptoms ... #rheumatology #
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... Cold Agglutinin Syndrome ... younger pts) Differential ... chills, flank pain ... hemolytic #anemia #hematology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... Presentation: Systemic Symptoms ... Sensory and/or motor neuropathy ... • Progressive symptoms ... #Rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Arthritis: • Joint pain ... • Peripheral neuropathy ... Induced Lupus: • Symptoms ... Erythematosus #Diagnosis #Rheumatology
Pulmonary Renal Syndromes - OnePager Summary
Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Autoimmune ANCA vasculitis ... EGPA) • Auto-antibodies ... or serologies + symptoms ... #differential # ... diagnosis #management