14 results
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
in Sickle Cell Disease ... other orthopedic complications ... #differential # ... diagnosis #causes ... #hematology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison

Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 •
Alcohol-induced pain ... : Pain in involved ... Diagnosis of B-Symptoms ... #differential # ... hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
(Cold-induced symptoms ... younger pts) Differential ... chills, flank pain ... hemolytic #anemia #hematology ... #diagnosis
Approach to Joint Pain

History:
Is the pain from:
	• Joint
	• Adjacent bursa
	• Tendon
	• Ligament
	• Bone
	• Muscle
	• Referred from
or nerve root Symptoms ... of Joint Disease ... #MSK #rheumatology ... approach #workup #differential ... #diagnosis #arthritis
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Vasculitides - Differential ... Diagnosis Framework ... Differential ... Presentation - Systemic Symptoms ... #diagnosis #rheumatology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
- Arthritis Differential ... Diagnosis Framework ... constitutional symptoms ... #Differential # ... Diagnosis #MSK #
Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS)
Fracture, Osteoporosis
 - Increased osteoclast activity and bone resorption
Complications of ... treatment of infective symptoms ... Ig deposition disease ... : chemotherapy Neuropathy ... #diagnosis #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
infections, bone pain ... extramedullary disease ... Transformation: • Complication ... #Leukemia #Hematology ... #Oncology #Diagnosis
Approach to Joint Pain - Diagnostic Framework

1) Chronicity
2) Inflammatory vs Non-Inflammatory
3) Number of Joints Involved

1) Chronicity:
Approach to Joint Pain ... - Diagnostic Framework ... alcohol - peripheral neuropathy ... #Joint #Pain #MSK ... approach #workup #differential
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Presentation: Systemic Symptoms ... Sensory and/or motor neuropathy ... tract: Abdominal pain ... • Progressive symptoms ... #Diagnosis #Rheumatology