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diagnosis differential management acute common cvid gap globulin hypogammaglobulinemia immunodeficiency immunology injury macrocytic macrocytosis oncology protein proteingap retroviral rheumatology sjogrens
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Differential Diagnosis Algorithm ... Myelodysplastic Syndromes ... #Macrocytosis #elevatedMCV ... #Causes #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... anemia) Labs ... anemia Treatment ... #hematology #diagnosis
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic ... Anemia • Toxic ... Non-lmmune: • HELLP Syndrome ... Prosthetic Heart Valve ... #Causes #Hematology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... Vascular Causes ... vein: Budd-chiari syndrome ... - If both are normal ... #hepatology
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
Hepatomegaly - Liver ... manifestations Labs ... enzymes ↑ • Mild anemia ... infection • Viral hepatitis ... antibody test) Treatment
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
disease • Liver ... diseases and hepatitis ... levels are within normal ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
changes (POEMS syndrome ... infections (acute HIV ... Sarcoidosis) • Liver ... gastric tumors • Hematology ... differential #diagnosis #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Ocular examination Labs ... TYPE IV RTA, TYPE ... vasculitis: 10%-16% Liver ... • Autoimmune hepatitis ... Adenocarcinoma Treatment
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