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diagnosis causes lfts antibodies associations autoantibodies cholangitis diseases erythematosus gap globulin hypertension injury interpretation liverenzymes lupus management pbc portal protein
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... • Pregnancy - AFLP ... US — Normal Bile ... • Alcoholic hepatitis ... Others #LFTs #Hepatology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Non-specific; common ... SLE, autoimmune hepatitis ... ) - Autoimmune hepatitis ... biliary cirrhosis ... diagnosis #table #rheumatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Autoimmune: Autoimmune hepatitis ... Chronic viral hepatitis ... : < 1 • Cirrhosis ... #injury #hepatitis ... #hepatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Primary Biliary ... Female:Male 9:1 • Common ... Diagnosis: • Viral hepatitis ... #Biliary #Cirrhosis ... diagnosis #workup #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs R-value ... Check Acute viral hepatitis ... Check Acute viral hepatitis ... Chronic viral hepatitis ... Hepatology #transaminitis
Portal Hypertension - Differential Diagnosis Portal Pressure = the pressure difference between the pressure in the portal
Clues to non-cirrhotic ... /acute hepatitis ... pregnancy • Primary ... biliary cirrhosis ... Diagnosis #causes #hepatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Ocular examination Labs ... • Autoimmune hepatitis ... , primary biliary ... cirrhosis: 3%-20% ... #Rheumatology #
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
the context of primary ... Noninfectious hepatitis ... , Serositis Labs ... common • Antihistone ... Erythematosus #Diagnosis #Rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
HBV, EBV, VZV, hepatitis ... disease: Cirrhosis ... PBC, PSC, Viral hepatitis ... gastric tumors • Hematology ... #diagnosis #hematology
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