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diagnosis management systemic vasculitis workup algorithm antinxp2 antinxp2dm autoantibodies classification comparison dermatomyositis druginduced leukemia lymphocytic mds mimickers myelodysplasia myelodysplastic polycythemia
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Cytopenias • Cardiac valve ... , Serositis Labs ... : • Chronic B-cell ... #Diagnosis #Rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Nephropathy 16% - Oral ... Auto-Antibodies ... autoantibodies #signs ... #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Epidemiology: -10% of all ... Erythematosus ( ... • Evolution: Chronic ... disease Dr. ... #table #rheumatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
non-Hodgkin lymphoma SLL ... Physical Exam/Signs ... cells can indicate disease ... CLL Labs: 1. ... #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Eosinophilia, asthma, chronic ... purpura: strong sign ... retinopathy Lab ... vasculitis, and SLE ... #diagnosis #rheumatology
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
that a one-off value ... Better call hematology ... exogenous, EPO levels: normal ... /high - Chronic ... Algorithm #workup #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Marrow Failure • Chronic ... Myeloproliferative Disease ... blood cells appear normal ... Syndromes #diagnosis #hematology ... #oncology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
• Antibodies targeting ... had more severe disease ... functional status Labs ... diagnosis #management #rheumatology ... #dermatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
, such as SLE, atherosclerotic ... purpura: Strong sign ... ischemia • Skin: Erythematous ... Eosinophilia, asthma, chronic ... #Diagnosis #Rheumatology
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
including systemic lupus ... erythematosus ( ... SLE), Sjögren’s ... plasma cells Labs ... diagnosis #management #rheumatology
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