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diagnosis hematology oncology algorithm treatment anemia chronic classification cll disease eosinophilia leukemia lymphocytic neurology vasculitis abdominal abnormal agglutinin als amyotrophic
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
incidentally during medical ... organ-specific signs ... or symptoms (eg ... Disorders #Algorithm #Differential ... #diagnosis #hematology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Dehydration • Symptoms ... changes, stroke symptoms ... WBC >100k, + lab signs ... TLS #diagnosis #management ... #hematology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Medium and large ... Behcet disease) Differential ... #diagnosis #management ... #signs #symptoms ... #rheumatology #
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Lymphocytes • Median ... immunophenotype Clinical ... Constitutional symptoms ... Leukemia #oncology #hematology ... hemeonc #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... syndrome associated ... Diagnosis: HLH signs ... and symptoms can ... #treatment #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Diagnosis: >3 symptoms ... initiation • Differential ... APML #diagnosis #management ... #hematology #oncology
Rare Causes of Abdominal Pain • Hereditary Angioneurotic Edema - Recurrent visceral that may by swelling
- May involve symptoms ... external factors • Median ... Positive Carnett's sign ... incisional hernias: clinical ... Abdominal #Pain #differential
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Viral Infection Clinical ... (Cold-induced symptoms ... younger pts) Differential ... hemolytic #anemia #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Aplastic Anemia Clinical ... • Improve the symptoms ... Anemia #oncology #hematology ... #diagnosis #management
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... with no early symptoms ... Physical Exam/Signs ... • Richter’s Syndrome ... workup #oncology #hematology
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