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liver obstetrics pregnancy algorithm comparison lfts biliary chemistry cholangitis cirrhosis disease fatty hematology injury interpretation liverenzymes management pathophysiology pbc primary
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
of Pregnancy (AFLP ... Hepatitis, Preeclampsia ... , HELLP, Intrahepatic ... iMedEducation #AFLP ... #obstetrics #obgyn
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
• Pregnancy - AFLP ... , HELLP Moderate ... • Alcoholic hepatitis ... Others #LFTs #Hepatology ... #Causes
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
phos/ULN ALP) ... • Near normal ... liver #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
of Pregnancy (AFLP ... #obstetrics #hepatitis ... #comparison #differential ... #diagnosis #icp ... #HELLP #AFLP
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Vascular Causes ... • Pregnancy: HELLP ... disease - If ALP ... hemolysis) • ALP ... #hepatology
Thrombocytopenia and Pregnancy Three syndromes in the critically ill pregnant woman who presents with coagulation defects. 1) HELLP
coagulation defects. 1) HELLP ... child * Severe cases ... #AFLP #Obstetrics ... #OBGyn #Hematology ... #Diagnosis #Comparison
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
intralobular bile ducts causes ... obstruction • ALP ... bile ducts Differential ... Viral hepatitis, ... #workup #hepatology
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