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diagnosis algorithm lfts causes obstetrics pregnancy ascites biliary chemistry cholangitis cirrhosis comparison enzymes fatty gap globulin hellp hematology injury interpretation
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
Liver Disease in ... of Pregnancy (ICP ... #hepatology #obstetrics ... #hepatitis #comparison ... #differential #
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
of cholestatic disease ... • Near normal ... disease: > 2 ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... function may be abnormal ... #injury #hepatitis ... #differential # ... diagnosis #algorithm #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... • Pregnancy - AFLP ... • Cholestatic disease ... • Alcoholic hepatitis ... Others #LFTs #Hepatology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
of Pregnancy (AFLP ... Antithrombin Ill • Ultrasound ... infiltration) Differential ... Diagnosis: Viral Hepatitis ... Pregnancy #hepatology
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... disease; T2DM, ... mellitus; USS, ultrasound ... #Algorithm #Hepatology ... #Differential #
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
obstruction • ALP ... or higher • Liver ... bile ducts Differential ... Diagnosis: • Viral hepatitis ... diagnosis #workup #hepatology
Causes of Ascites Normal Peritoneum Portal hypertension (SAAG > 1.1 g/dL) 1. Hepatic congestionl
Causes of Ascites Normal ... Liver disease ... - Alcoholic hepatitis ... Causes #diagnosis #differential ... #hepatology #SAAG
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
• Heavy chain disease ... Sarcoidosis) • Liver ... disease: Cirrhosis ... chain assay • An abnormal ... Gap #ProteinGap #differential
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