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management rheumatology syndrome cppd differential hemophagocytic hlh lupus lymphohistiocytosis neurology signs symptoms table activation behcet calcium centralretinalartery cerebritis cns crao
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... Cerebrovascular Disease ... , PRES Pathophysiology ... : • Inflammatory ... Erythematosus #SLE
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... production of pro-inflammatory ... • Autoimmune diseases ... : SLE+++, Adult-onset ... Still disease,
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
life-threatening • Treatment ... Evolution: Chronic disease ... #comparison #table ... #rheumatology # ... diagnosis #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
release of pro-inflammatory ... erythematosus [SLE ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
(25-75%): Inflammatory ... Oral aphthae : SLE ... • Arthritis: SLE ... Arthritis, AS Treatment ... signs #symptoms #rheumatology
Central Retinal Artery Occlusion: Pathogenesis and clinical findings • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
clinical findings • Inflammatory ... GCA, SLE, GPA) - ... anti-coagulation • Hematologic ... Occlusion #CRAO #pathophysiology ... ophthalmology #diagnosis
Scleroderma Like Conditions - Differential Diagnosis Eosinophilic Fasciitis: - Orange peel induration (peau d'orange) of proximal extremities
- Differential Diagnosis ... the mainstay of treatment ... myeloma or AL amyloidosis ... #comparison #table ... #dermatology
CPPD vs Gout == CPPD == Think About CPPD When: • Self-limited synovitis after surgery/trauma (> 65
• Underlying disease ... states Pathophysiology ... #CPPD #Gout #Comparison ... #rheumatology # ... Diagnosis
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... Sjogren's Syndrome Diagnosis ... PE, Pulmonary amyloidosis ... Nephrogenic DI Hematologic ... Adenocarcinoma Treatment
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Overview Focal inflammatory ... monophasic Pathophysiology ... Evaluate for NMO, SLE ... Disorders: - SLE ... Transverse Myelitis Treatment
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