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differential management neurology rheumatology hematology infections syndrome aids bee behcet chronic encephalitis hemophagocytic hiv hlh infectiousdiseases inflammatory leukemia lymphocytic lymphohistiocytosis
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
• IRIS might ... should be based on clinical ... required until immune ... Demyelinating disease ... Syphilis • Aspergillosis
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
) - Clinical Manifestations ... pain/pain upon eye ... pain • Extra-CNS ... #neurology #symptoms ... #signs
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
worsening of that disease ... No specific diagnostic ... initiation Clinical ... pleural effusions, CNS ... weeks for most OI
BEE Syndromes - Non-inflammatory Causes Immune-mediated conditions affecting the Brain, Eye, and Ear Visual or auditory symptoms in
Non-inflammatory Causes Immune-mediated ... affecting the Brain, Eye ... nervous system (CNS ... Infectious • Syphilis ... MRI lesions and clinical
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
rendering the immune ... Orange or Hep C Clinical ... early symptoms ... Physical Exam/Signs ... cells can indicate disease
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
association • M > F Clinical ... : Inflammatory eye ... symptoms (headache ... : No pathognomonic ... #management #signs
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Presentation: Systemic Symptoms ... Arthralgias • Eye ... purpura: Strong sign ... • Progressive symptoms ... chorioretinitis, CNS
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... underlying genetic immune ... age, however the disease ... : HLH signs and ... symptoms can mimic
CNS Infections - Viral Encephalitis and Bacterial Meningitis - Differential Diagnosis Framework Viral Encephalitis: MCC: Enteroviruses (e.g., coxsackievirus
CNS Infections - ... • Common clinical ... • In tertiary syphilis ... Acute meningeal signs ... Develops in the immune
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
that results in CNS ... • Immune Mediated ... Transverse Myelitis - Clinical ... • Bilateral signs ... and/or symptoms
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