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diagnosis hematology leukemia cll lymphocytic syndrome differential differentiation hemeonc immune inflammatory mds myelodysplasia myelodysplastic reconstitution syndromes workup
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, APML, CLL Acute ... rapid onset of symptoms ... Chronic leukemia ... onset of symptoms ... Leukemia #Hematology #Oncology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome in APML ... Release from blast cells ... Diagnosis: >3 symptoms ... #diagnosis #management ... #hematology #oncology
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
increase in CD4+ cells ... leukoencephalopathy (PML ... with severe symptoms ... weeks for most OI ... Differential #Diagnosis #Management
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... lymphocytes, smudge cells ... uw_IMresidency #CLL #Chronic ... Lymphocytic #Leukemia #oncology ... hemeonc #diagnosis #management
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... with no early symptoms ... Transform to DLBCL, PML ... leukemia #CLL #Chronic ... diagnosis #workup #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... transformation to AML ... Marrow Failure • Chronic ... progression to AML ... diagnosis #hematology #oncology
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