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diagnosis hematology syndrome differential leukemia rheumatology behcet cll differentiation disease immune lymphocytic mds myelodysplasia myelodysplastic reconstitution signs vasculitis workup
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... onset of symptoms ... develop leukostasis syndrome ... • Tumor lysis syndrome ... Leukemia #Hematology #Oncology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Release from blast cells ... Diagnosis: >3 symptoms ... #management #hematology ... #oncology
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
Syndrome - Overview ... increase in CD4+ cells ... weeks for most OI ... #Syndrome #Differential ... #Diagnosis #Management
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... with no early symptoms ... • Richter’s Syndrome ... leukemia #CLL #Chronic ... diagnosis #workup #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... transformation to AML ... Marrow Failure • Chronic ... progression to AML ... diagnosis #hematology #oncology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Disease (25-75%): Inflammatory ... eye disease (panuveitis ... Recurrent and chronic ... #diagnosis #management ... #signs #symptoms
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Presentation: Systemic Symptoms ... Arthralgias • Eye ... • Progressive symptoms ... Eosinophilia, asthma, chronic ... : Ocular inflammatory
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