11 results
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS

What Is IRIS?
	• A state of hyperinflammatory response that
Reconstitution Inflammatory Syndrome ... increase in CD4+ cells ... weeks for most OI ... #Inflammatory #Syndrome ... Differential #Diagnosis #Management
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
- Antithyroid medications ... Idiopathic • Infections ... • Improve the symptoms ... Anemia #oncology #hematology ... #diagnosis #management
Anti-IL6 Agents (Tocilizumab, Siltuximab) in COVID19

IL-6 activates T cells and macrophages, among other cell types (see
-6 activates T cells ... Cytokine Activation Syndrome ... respiratory tract infection ... Siltuximab #COVID19 #Pharmacology ... #Management #Medications
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
lymphocytes, smudge cells ... Complications: 1) Infection ... low-risk disease • Indications ... Leukemia #oncology #hematology ... hemeonc #diagnosis #management
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Diagnosis: >3 symptoms ... Differential Diagnosis: Infection ... APML #diagnosis #management ... #hematology #oncology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
to exclude are infections ... Presentation: Systemic Symptoms ... Arthralgias • Eye ... Multinucleated giant cells ... • Progressive symptoms
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... Diagnosis: • Dry eyes ... Nephrogenic DI Hematologic ... lubricants • Pharmacologic ... Diagnosis #Management
IDSA Recommendations for Treating Cytomegalovirus Infections in HIV-AIDS
Preventing CMV Disease:
 • CMV end-organ disease is best
CD4 count >100 cells ... ., concomitant medications ... contralateral eye ... Prevention #Treatment #management ... #HIVAIDS #pharmacology
TAFRO

TAFRO syndrome was first described in 2010, standing for:
- Thrombocytopenia
- Anasarca
- Fever
- Reticulin fibrosis
- Organomegaly

TAFRO syndrome
vasculitis - Infectious ... fast bacterial infection ... and the systemic symptoms ... TAFRO #diagnosis #management ... #rheumatology #
Relapsing Polychondritis

What is it?
Recurrent inflammation of the cartilage in the body (Autoimmune disorder)

Who?
• Most frequently: 40
ethnicities Symptoms ... + Nonspecific symptoms ... vessels (aorta) • Eyes ... Behcet disease • Infections ... #diagnosis #management