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diagnosis differential hematology hemophagocytic hlh lymphohistiocytosis rheumatology treatment vasculitis acquired cell chronic classification community hemeonc histiocytosis inflammatory langerhans lch leukemia
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
rendering the immune ... is identical to ... with no early symptoms ... Physical Exam/Signs ... cells can infiltrate
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
Inflammatory Syndrome ... What Is IRIS ... which can occur ... weeks for most OI ... Differential #Diagnosis #Management
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Diagnosis and Management ... activity → local immune ... Pulmonary: dyspnea ... acute sarcoidosis Pulmonary ... #Signs #Symptoms
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Presentation: Systemic Symptoms ... Arthralgias • Eye ... purpura: Strong sign ... GCA (Giant Cell ... • Progressive symptoms
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... underlying genetic immune ... Diagnosis: HLH signs ... and symptoms can ... Lymphohistiocytosis #diagnosis #management
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Necrotizing, pauci-immune ... Presentation - Systemic Symptoms ... Arthralgias • Eye ... purpura: strong sign ... Eye -> retinopathy
Community Acquired Pneumonia (CAP) - Diagnosis and Management Pneumonia Signs/Symptoms: • Confusion/disorientation (LR + 1.9) • Cough
Diagnosis and Management ... Pneumonia Signs ... /Symptoms: • Confusion ... count < 4,000 cells ... #treatment #Pulmonary
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... activation of the immune ... with the HLH syndrome ... Presentation • Common Signs ... and Symptoms:
Langerhans Cell Histiocytosis (LCH) Granulomatous Lesions comprising langerin-positive histiocytes and an inflammatory infiltrate can arise in virtually
inflammatory infiltrate can ... involved in immune ... • Pulmonary Symptoms ... crucial in pulmonary ... Histiocytosis #Diagnosis #Management
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