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management rheumatology infectiousdiseases summary adultonset arthritis cap community disease fusarium gca giantcell hematology hemophagocytic hlh infections lymphohistiocytosis macrophage mas pneumonia
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... the secondary or acquired ... (sJIA) • Adult-onset ... Treatment: • Corticosteroids ... #Syndrome #Diagnosis
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Disease Clinical ... Fever, Arthralgia/arthritis ... hepatitis • Pulmonary ... #management #treatment
Septic Arthritis - Diagnosis and Management Summary Clinical Exam: hot, swollen, pain with passive AND active ROM
Management Summary Clinical ... osteomyelitis, trauma ... diagnosis Treatment ... washout • Healthy Adults ... pediatrics but NOT adults
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... accumulation of clinical ... Assessment • Clinical ... Purtilo (XLP) Acquired ... diseases: SLE+++, Adult-onset
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
vasculitis in older adults ... Diagnosis = clinical ... of the steroid treatment ... Treatment of GCA ... w/in 24 hours) required
Community Acquired Pneumonia (CAP) - Diagnosis and Management Pneumonia Signs/Symptoms: • Confusion/disorientation (LR + 1.9) • Cough
Community Acquired ... Pneumonia (CAP) - Diagnosis ... be initiated in adults ... with clinically ... #Pulmonary #Community
Toxocariasis Pathogen: Toxocara - worldwide distributed helminth Transmission: • Dogs and cats are the major source
• Humans acquire ... Adult worms develop ... larva migrans Diagnosis ... • History + clinical ... #microbiology
Fusarium Infections Acquired through: 1. Inhalation of airborne conidia > germinates > blood > disseminated 2. Trauma (implantation with
Fusarium Infections Acquired ... Trauma (implantation ... incubation 4 major clinical ... Refractory FUO, Sino-pulmonary ... disease: • Optimal treatment
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