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liver hematology treatment algorithm hepatitis transaminitis aflp causes gastroenterology hemophagocytic hlh injury lymphohistiocytosis obstetrics pathophysiology pregnancy rheumatology abnormal aclf acromegaly
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Chronic - ongoing ↑ LFTs ... Idiosyncratic #differential ... #Diagnosis #Management ... gastroenterology #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... Differential Diagnosis ... (>1000): • DILI ... #Differential # ... Diagnosis #hepatology
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Transaminitis - Differential ... Diagnosis • ... Trauma: Shock liver ... • Iatrogenic: DILI ... #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Failure (ACLF) Clinical ... Injury (DILI) ... Failure #Cirrhosis #Hepatology ... gastroenterology #management ... #diagnosis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... • Gilbert's syndrome ... #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... Diagnosis Algorithm ... vein: Budd-chiari syndrome ... #diagnosis #algorithm ... #hepatology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
10x ULN), ↑Tbili/Dbili ... infiltration) Differential ... Diagnosis: Viral ... Maternal Support - Critical ... #Pregnancy #hepatology
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
presence of metabolic syndrome ... #LFTs #Abnormal ... #Algorithm #Hepatology ... #Differential # ... Diagnosis
Portal Hypertension - Differential Diagnosis Portal Pressure = the pressure difference between the pressure in the portal
Hypertension - Differential ... Diagnosis Portal ... >10 mmHg - clinically ... #Diagnosis #causes ... #hepatology
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
weeks • Typical clinical ... necrosis HELLP Syndrome ... Disease #Pregnancy #hepatology ... hepatitis #comparison #differential ... #diagnosis #icp
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