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diagnosis liver gastroenterology transaminitis aclf acute aflp algorithm chemistry chronic drug fatty function idiosyncratic induced interpretation obgyn obstetrics pathophysiology pregnancy
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... • NAFLD • Cirrhosis ... (>1000): • DILI ... injury) • Ischemic ... Diagnosis #hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Injury (DILI) ... Chronic - ongoing ↑ LFTs ... #differential # ... gastroenterology #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Clinical Guidelines ... those with CLD (± cirrhosis ... Injury (DILI) ... #Failure #Cirrhosis ... #Hepatology #gastroenterology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Failure (ALF): ... • Liver injury ... hepatitis: < 1 • Cirrhosis ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
failure rapidly ... → Multiorgan failure ... 10x ULN), ↑Tbili/Dbili ... infiltration) Differential ... #Pregnancy #hepatology
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