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diagnosis liver injury abnormal management acute alkaline alp anemia biliary cholangitis cirrhosis elevated elevatedmcv elevation enzymes fatty gastroenterology hematology hepatitis
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Liver Injury (DILI ... Chronic - ongoing ↑ LFTs ... Idiosyncratic #differential ... gastroenterology #algorithm ... gastroenterology #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
• Wilson's • Pregnancy ... - AFLP, HELLP ... • Others #LFTs ... #Hepatology #LiverEnzymes ... #Causes
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... AIH, Wilsons, Pregnancy ... Burak @kwburak #LFTs ... #diagnosis #hepatology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
) Elevation - Differential ... Diagnosis Algorithm ... Intestine - Other causes ... - Pregnancy ... #hepatology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
of Pregnancy (AFLP ... = nonspecific (nausea ... 10x ULN), ↑Tbili/Dbili ... infiltration) Differential ... Pregnancy #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... Vascular Causes ... melanoma, myeloma • Pregnancy ... • Iatrogenic: DILI ... #hepatology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Diagnosis Algorithm ... Blood Smear • Drugs ... Pregnancy) - Low ... #Causes #Hematology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Liver Injury - Differential ... , Recreational Drugs ... Toxic: Medication, Pregnancy ... #Acute #algorithm ... #hepatology
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
tests algorithm ... ALP, alkaline phosphatase ... #LFTs #Abnormal ... #Algorithm #Hepatology ... #Differential #
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
intralobular bile ducts causes ... bile ducts Differential ... cholestasis of pregnancy ... , Sarcoidosis, Drug-induced ... diagnosis #workup #hepatology
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