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diagnosis differential causes hematology treatment ascites pathophysiology acute aflp algorithm cirrhosis hemophagocytic hlh lfts lymphohistiocytosis manifestations obstetrics pregnancy rheumatology saag
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic Liver ... Clinical Guidelines ... disease, liver ... support, or liver ... #Hepatology #gastroenterology
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
Non-Malignant • Fatty Liver ... • Right Heart Failure ... • Budd-Chiari Syndrome ... Infectious • Hepatitis ... Algorithm #Causes #Hepatology
Ascites - Differential Diagnosis Chronic liver disease (cirrhosis or chronic hepatitis) - 80% Underlying malignancy - 10% Congestive heart
Diagnosis Chronic liver ... cirrhosis or chronic hepatitis ... Congestive heart failure ... Fitz-Hugh-Curtis syndrome ... Differential #Diagnosis #hepatology
Common Etiologies of Cirrhosis Inflammation - Hepatitis B (15 percent) - Hepatitis C (47 percent) - Schistosomiasis
Inflammation - Hepatitis ... Nonalcoholic fatty liver ... Congestive heart failure ... disease (Budd-Chiari syndrome ... #Differential #Hepatology
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 Clinical manifestations of acute liver failure Brain: Hepatic encephalopathy, Cerebral edema, Intracranial hypertension,
Clinical manifestations ... of acute liver ... abnormalities Liver ... Heart: High output ... manifestations #acute #liver
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... hepatocytes → Liver ... malaise) → Acute liver ... Transfer to a liver ... #AFLP #Fatty #Liver
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
Liver Disease in ... necrosis HELLP Syndrome ... Hemolysis, Elevated Liver ... features: Liver ... BrighamChiefs #Liver
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Liver Chemistries ... Failure (ALF): ... • Liver injury ... • Gilbert's syndrome ... #differential #Hepatology
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
disease to acute liver ... failure ... hepatocellular pattern of liver ... (eg Viral) Management ... #Hepatology
Causes of Ascites Normal Peritoneum Portal hypertension (SAAG > 1.1 g/dL) 1. Hepatic congestionl
- Heart failure ... Liver disease ... - Alcoholic hepatitis ... - Acute fatty liver ... #differential #hepatology
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