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differential generalized secondary cold common cvid erythematosus gap globulin hypogammaglobulinemia immunodeficiency immunology lupus lymphocytic management mds myelodysplasia myelodysplastic primary protein
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... Syndrome (CAS): ... Diagnosis: • hemolytic ... #disease #hemolytic ... #anemia #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Coombs (-) hemolytic ... anemia due to cold ... #Hematology #Monoclonal ... #Differential #Diagnosis ... #Oncology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Algorithm - Systemic ... • Leukemia ... Myelodisplastic syndrome ... #generalized #dermatology ... #Algorithm #causes
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... -> Invade Skin: ... lymphoma #Leukemia ... #Hematology #Oncology ... #Diagnosis
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Skin Lesion - Differential ... Diagnosis Algorithm ... • Leukemia ... #generalized #dermatology ... #Algorithm #causes
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Hepatomegaly • Skin ... • Neutropenia, anemia ... #Leukemia #diagnosis ... #workup #oncology ... #hematology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
disease. ... Causes: - Idiopathic ... (malignancy), lymphoma ... #diagnosis #dermatology ... #oncology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to impaired B-cell ... and autoimmune hemolytic ... anemia) • Systemic ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Causes of Monoclonal ... gastric tumors • Hematology ... : Lymphoma, Leukemia ... anemia • Other ... #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... lymphopenia, low PLT • Anemia ... with Lupus: • Chronic ... and leukemia • ... #Rheumatology
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