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Acute Treatment of Migraine

- BWH Medicine Chiefs @BrighamChiefs

#Migraine #Treatment #management #neurology #headache #medications
Acute Treatment ... of Migraine - ... #Treatment #management ... #neurology #headache ... #medications
Diuretics sites of action on the nephron
1) Acetazolamide (carbonic anhydrase inhibitor)
2) Osmotic diuretics (e.g. mannitol)
3) Loop
inhibitor) 2) Osmotic ... #pharmacology #nephrology ... #medications #sites
Acute Treatment of Migraine
Mild Attacks: NSAIDs, Simple Analgesics
Moderate/Severe Attacks: Triptans, Ditans, Gepants, Ergots
Non-pharmacologic Treatment: Neuromodulation, Rest,
Acute Treatment ... of Migraine Mild ... Rest, Hydration, Meditation ... neudrawlogy #Migraine ... #management #neurology
Pharmacotherapy for Migraine Prophylaxis 

Who is indicated for migraine prophylaxis? Patients who experience more than 3
Pharmacotherapy for Migraine ... indicated for migraine ... appropriate acute treatment ... #Prophylaxis #Medications ... Pharmacology #Management #Neurology
Chronic Diarrhea Differential Diagnosis
 • Inflammatory, Infectious: Recurrent C. diff, Giardiasis
 • Inflammatory, Non-infectious: IBD, Ischemia,
, Radiation • Osmotic ... Lactose intolerance, Medication ... Dysmotility: IBS, Medications
Summary of Diuretic Agents 
Subclass, Drug, Mechanism of Action, Effects, Clinical Applications, Pharmacokinetics, Toxicities, Interaction
CARBONIC ANHYDRASE
• Triamterene OSMOTIC ... #Diuretics #Medications ... summary #table #nephrology
Irritable Bowel Syndrome (IBS) Treatment Algorithm

IBS-Constipation:
 • Constipation: Osmotic laxatives
 • Abdominal pain: Antispasmodics

IBS-Diarrhea:
 • Diarrhea:
Syndrome (IBS) Treatment ... Constipation: Osmotic ... Syndrome #IBS #Treatment
Prophylactic Migraine Medications

Established Efficacy: 
 • Metoprolol, Propranolol, Timolol, Divalproex, Valproate, Topiramate, Frovatriptan
Probably Effective: 
 •
Prophylactic Migraine ... Medications ... Cyproheptadine #Migraine ... #prophylaxis #Medications ... pharmacology #EBM #neurology
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
canagliflozin 2) Osmotic ... Sites #Action #nephrology
Hormones Acting on the Nephron - Diuretics and Their Site of Action
 1) Acetazolamide
 2) Osmotic
Acetazolamide 2) Osmotic ... Pathophysiology #Nephrology