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diagnosis hematology management oncology apml bloodsmear chronic clinical cll differentiation hemophagocytic hlh leukemia leukostasis lymphocytic lymphohistiocytosis lysis microscopy pathology recurrentis
Borrelia recurrentis on Peripheral Blood Smear 23M Somali refugee recently arrived w/severe abd pain, confusion and fever
Syndrome: 3d of ... Specific organ injury ... of blood smear, acute ... often experience acute ... initiation of treatment
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
- 80% have fever ... - ACS, AKI, acute ... lab signs of end organ ... damage • Treatment ... diagnosis #management #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... : • Common: fever ... Renal Failure Treatment ... unless severe APLS, organ
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
adults in the west ... Lymphadenopathy • Fevers ... microglobulin Treatment ... ’s lymphoma or acute ... Leukemia #diagnosis #workup
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... presents as an acute ... with multiple organ ... following: • Fever ... #hematology
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