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diagnosis hematology management oncology differential anemia hemolytic agglutinin apml cancer chronic classification cold differentiation disease eosinophil eosinophilia hemophagocytic hlh hodgkins
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
adults in the west ... Lymphadenopathy • Fevers ... lymphoproliferative disorders ... microglobulin Treatment ... Leukemia #diagnosis #workup
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... Testing Algorithm ... evaluation or workup ... glucocorticoid treatment ... #diagnosis #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Symptoms: High fevers ... • Diagnostic Test ... Donath-Landsteiner test ... hemolytic #anemia #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Differential Diagnosis Algorithm ... Consider sickle cell ... bartonella (oroya fever ... Consider RBC membrane disorder ... #workup #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... formed or don’t work ... Neutropenia • Platelet Disorders ... agents given to organ ... Workup: • Complete
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... • Induce blast cell ... Subacute-Acute: • Common: fever ... Renal Failure Treatment
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... with multiple organ ... following: • Fever ... Low or absent NK cell ... #hematology
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Differential Diagnosis Algorithm ... Better call hematology ... always a good idea ... Best to have an ... #workup #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
accounts for 10% of all ... • Autoimmune disorders ... • Dyspnea • Fever ... Hodgkin Lymphoma Workup ... Hodgkin Lymphoma Treatment
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
- Anasarca - Fever ... which is a rare disorder ... disease, severe fever ... Hypoalbuminemia Treatment ... diagnosis #management #rheumatology
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