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diagnosis hematology management oncology dermatology activation acute anesthesia anesthesiology apml bowel brucellosis causes checklist chronic classification cll dermatosis differential differentiation
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
- Nonremitting fever ... Liver function tests ... Histopathologic criteria ... Treatment: • Corticosteroids ... #Rheumatology
Diagnosing Brucellosis Epidemiological Exposures - Endemic Regions - Clinical Micro Lab Technicians - Animal/Vaccine Exposure: Vets, Slaughterhouse workers, hunters - Unpasteurized
Constitutional: Fevers ... Weight loss - End Organ ... Genitourinary Diagnostic Tests ... Brucellosis #Diagnosis #Criteria ... #Workup #Testing
Irritable Bowel Syndrome (IBS) - Diagnosis and Workup Summary Use a positive diagnostic strategy with minimal testing.
Irritable Bowel Syndrome ... Diagnosis and Workup ... Rome IV Criteria ... cultures, but test ... missing things" → fewer
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
- 80% have fever ... lab signs of end organ ... damage • Treatment ... Low calcium • Treatment ... diagnosis #management #hematology
Peri-operative Hyperthermia - Guidelines for Crises in Anaesthesia If prolonged or ≥ 39 C this is a
emergency: permanent organ ... Treatment depends ... Actively maintained fever ... • Serotonin syndrome ... Diagnosis #Management #Workup
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
adults in the west ... Lymphadenopathy • Fevers ... infiltrate any organ ... microglobulin Treatment ... Leukemia #diagnosis #workup
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Definition: • Severe adverse drug reaction, characterized by
with visceral organ ... Criteria for Diagnosis ... Fever >38.5 2. ... disease: symptomatic treatment ... SinaiBmoreIMRes #DRESS #Syndrome
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Subacute-Acute: • Common: fever ... Renal Failure Treatment ... unless severe APLS, organ
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... with multiple organ ... following: • Fever ... • Bicytopenia Treatment ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... agents given to organ ... factor (GCSF) treatments ... Workup: • Complete ... #diagnosis #hematology
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