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diagnosis management hematology oncology activetb hlh latenttb lymphohistiocytosis tb tuberculosis apml chagas chronic classification cll differentiation disease hodgkins leukemia lymphocytic
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... A subset of hemophagocytic ... SLE], AOSD) • Infection ... Liver function tests ... Treatment: • Corticosteroids
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... excessive macrophage activation ... with multiple organ ... following: • Fever ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hemophagocytic Lymphohistiocytosis ... →Activation of CD8 ... IFN-y) → Excessive activation ... • Clinical: fever ... #summary #rheumatology
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
Active TB: • Fever ... Can involve any organ ... Tuberculosis Treatment ... Initiating Treatment ... Diagnosis #Management #Treatment
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
Active TB: • Fever ... Can involve any organ ... Tuberculosis Treatment ... Initiating Treatment ... Diagnosis #Management #Treatment
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
adults in the west ... Lymphadenopathy • Fevers ... weeks without infection ... microglobulin Treatment ... Leukemia #diagnosis #workup
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Subacute-Acute: • Common: fever ... Differential Diagnosis: Infection ... Renal Failure Treatment
Chagas Disease - American Trypanosomiasis - Diagnosis and Management Summary Chagas disease (American trypanosomiasis) is an infectious
family Route of infections ... Organ transplantation ... mild (malaise, fever ... Confirmatory Tests ... and immunoblot (TESA
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... petechiae) • Frequent infections ... • Parvovirus infection ... agents given to organ ... Workup: • Complete
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
History of EBV infection ... • Dyspnea • Fever ... Hodgkin Lymphoma Workup ... check for other organ ... Hodgkin Lymphoma Treatment
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