4 results
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... endothelial damage • Induce ... Imaging: CXR- pulmonary ... Differential Diagnosis: Infection ... #management #hematology
Amiodarone Induced Lung Toxicity Summary

Who?
• 5% of patients
• Dose ≥ 400 mg per day

How?  Possible
organizing pneumonia, ARDS ... distress syndrome ... failure - Infectious ... pulmonary toxicity ... #management #Toxicology
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS

What Is IRIS?
	• A state of hyperinflammatory response that
Reconstitution Inflammatory Syndrome ... baseline or both • Rule ... Drug reaction/ART toxicity ... #Inflammatory #Syndrome ... Differential #Diagnosis #Management
Myelodysplastic syndromes current treatment algorithm 2018.

From Blood Cancer Journal, Published 24 May 2018

Myelodysplastic syndromes (MDS) are
clonal evolution to acute ... cardiovascular or pulmonary ... risk of organ toxicity ... may result in an infection ... approved by the Food