8 results
Prader-Willi Syndrome: Pathogenesis and clinical findings
 • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Prader-Willi Syndrome ... fractures • Short ... Obesity -> Type 2 diabetes ... sleep apnea, cor pulmonale ... #genetics #pathophysiology
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
irrigation • Management ... Bumetanide, Ethacrynic acid ... Torsemide) • Acute pulmonary ... Lithium-induced nephrogenic diabetes ... DDAVP) • Central diabetes
Guillain-Barre Syndrome - Summary

Acute AIDP that presents with rapidly progressive flaccid weakness

Epidemiology:
 • 1-2 cases/100,000 per
Guillain-Barre Syndrome ... Guillain-Barre Pathophysiology ... • Weakness: Starts ... : Due to nerve root ... #diagnosis #management
Thiamine Deficiency - Differential Diagnosis Framework and Clinical Manifestations

Causes of Thiamine Deficiency:
 • Poor intake:
	- Diets
gravidarum - Diuretic ... - Refeeding syndrome ... HF • Moderate pulmonary ... : - Impaired short-term ... beriberi #nutrition #pathophysiology
Acid Base Disorders - Blood Gas Interpretation

Steps for Blood Gas Interpretation: 
1. Acidemia or Alkalemia? 
2.
Acid Base Disorders ... bowel syndrome, ... Ketoacidosis (starvation, diabetic ... Classically” noted with pulmonary ... ABG #bloodgas #Acid
There are similarities and differences between these 3 conditions which all carry treatment implications. Each mimic
mobilizes fatty acids ... produce Acetoacetic acid ... for Refeeding Syndrome ... drips unless also diabetic ... differential #algorithm #management
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
with thiazide diuretic ... Hypocalciuria (spot ... Surreptitious diuretic ... diagnosis #nephrology #management ... #pathophysiology
Mycoses

HISTOPLASMOSIS
• Inhalation of conidia → Yeast → travel to lymph nodes → spread in body
• Bird
host): • Chronic pulmonary ... MUCORMYCOSIS • Risk: Diabetes ... Inhalation of spores ... Aspergillosis Pathophysiology ... Fungal #Diagnosis #Management