17 results
Antiplatelet Conversion - Switching Between P2Y12 Inhibitors
Oral P2Y12 inhibitors vary in potency and pharmacokinetic and dynamic
Clopidogrel to Prasugrel ... De-escalation in Potency: Prasugrel ... High Potency: Prasugrel ... Ticagrelor to Prasugrel ... antiplatelet #ticagrelor #prasugrel
Trends in Platelet Adenosine Diphosphate P2Y12 Receptor Inhibitor Use and Adherence Among Antiplatelet-Naive Patients After Percutaneous
Adenosine Diphosphate P2Y12 ... Inhibitor Use and Adherence ... EBM #Cardiology #Adherence ... #Clopidogrel #Prasugrel
Antiplatelet Medications - Summary Table

Aspirin - Inhibits cyclooxygenase, preventing formation of thromboxane A2
 • Acute coronary
combination with P2Y12 ... anticoagulation in a-fib P2Y12 ... (clopidogrel, prasugrel ... - Inhibits the P2Y12
Antiplatelet Conversion - P2Y12 Inhibitor Switching
 • Clopidogrel (Plavix)
 • Prasugrel (Effient)
 • Ticagrelor (Brilinta)
Clopidogrel and
Antiplatelet Conversion - P2Y12 ... Clopidogrel (Plavix) • Prasugrel ... Clopidogrel and prasugrel ... active site of the P2Y12 ... Antiplatelet #Conversion #P2Y12
Oral P2Y12 Inhibitor Pharmacology

 • Clopidogrel
 • Prasugrel
 • Ticagrelor

By Kyle Fischer, PharmD @Kfischer_10

#P2Y12 #Inhibitor #Pharmacology
Oral P2Y12 Inhibitor ... Clopidogrel • Prasugrel ... Kfischer_10 #P2Y12
Antiplatelet Conversion - Switching Between Oral P2Y12 Inhibitors
A, Switching between oral agents in the acute/early phase.
Switching Between Oral P2Y12 ... escalating to prasugrel ... hours after last prasugrel ... ticagrelor to prasugrel ... CIRCULATIONAHA.117.031164 #P2Y12
Cangrelor - Pharmacology
Cangrelor (Kengreal) is a parenteral analogue of adenosine triphosphate
Cangrelor binds reversibly to the platelet
to the platelet P2Y12 ... pre-treated with an oral P2Y12 ... Antiplatelet: • Both prasugrel ... if the platelet P2Y12 ... clopidogrel and prasugrel
HIV PrEP (Pre-Exposure Prophylaxis) - Truvada 

HIV Pre-Exposure Prophylaxis (PrEP) is available in the form of
meet with their clinician ... counseled for adherence ... Adherence to the
Forrest Classification for Peptic Ulcer Bleeding
Rebleeding risks are without endoscopic intervention
1a - Spurting Bleed - 60-100%
Re-bleeding IIb - Adherent ... gastroenterology #EGD #clinical
Daliresp (Roflumilast) 
Indication: Reduce risk of COPD exacerbations 
Drug Class: Selective Phosphodiesterase-4 (PDE4) Inhibitor 
GOLD 2019
exacerbations while adherent ... won’t have any clinical