11 results
Antiplatelet Conversion - Switching Between P2Y12 Inhibitors
Oral P2Y12 inhibitors vary in potency and pharmacokinetic and dynamic
Clopidogrel to Prasugrel ... De-escalation in Potency: Prasugrel ... High Potency: Prasugrel ... Ticagrelor to Prasugrel ... antiplatelet #ticagrelor #prasugrel
Trends in Platelet Adenosine Diphosphate P2Y12 Receptor Inhibitor Use and Adherence Among Antiplatelet-Naive Patients After Percutaneous
Adenosine Diphosphate P2Y12 ... Inhibitor Use and Adherence ... EBM #Cardiology #Adherence ... #Clopidogrel #Prasugrel
Antiplatelet Medications - Summary Table

Aspirin - Inhibits cyclooxygenase, preventing formation of thromboxane A2
 • Acute coronary
combination with P2Y12 ... anticoagulation in a-fib P2Y12 ... (clopidogrel, prasugrel ... - Inhibits the P2Y12
Antiplatelet Conversion - P2Y12 Inhibitor Switching
 • Clopidogrel (Plavix)
 • Prasugrel (Effient)
 • Ticagrelor (Brilinta)
Clopidogrel and
Antiplatelet Conversion - P2Y12 ... Clopidogrel (Plavix) • Prasugrel ... Clopidogrel and prasugrel ... active site of the P2Y12 ... Antiplatelet #Conversion #P2Y12
Oral P2Y12 Inhibitor Pharmacology

 • Clopidogrel
 • Prasugrel
 • Ticagrelor

By Kyle Fischer, PharmD @Kfischer_10

#P2Y12 #Inhibitor #Pharmacology
Oral P2Y12 Inhibitor ... Clopidogrel • Prasugrel ... Kfischer_10 #P2Y12
Antiplatelet Conversion - Switching Between Oral P2Y12 Inhibitors
A, Switching between oral agents in the acute/early phase.
Switching Between Oral P2Y12 ... escalating to prasugrel ... hours after last prasugrel ... ticagrelor to prasugrel ... CIRCULATIONAHA.117.031164 #P2Y12
Forrest Classification for Peptic Ulcer Bleeding
Rebleeding risks are without endoscopic intervention
1a - Spurting Bleed - 60-100%
Re-bleeding IIb - Adherent ... gastroenterology #EGD
Forrest Classification of Upper GI Bleeding
Acute Hemorrhage
  Ia - Active Spurting, Re-bleeding Risk 60-100%
40-50% IIb - Adherent ... gastroenterology #egd
Forrest Classification for Describing Endoscopic Findings in Patients With Bleeding Ulcers and Predicting Risk of Rebleeding

Classification
liquid  IIb  Adherent ... Classification #Endoscopy #EGD
Cangrelor - Pharmacology
Cangrelor (Kengreal) is a parenteral analogue of adenosine triphosphate
Cangrelor binds reversibly to the platelet
to the platelet P2Y12 ... pre-treated with an oral P2Y12 ... Antiplatelet: • Both prasugrel ... if the platelet P2Y12 ... clopidogrel and prasugrel