14 results
Features of a Sickle Cell Crisis 
Sickle-cell disease - an autosomal recessive blood disorder.
Characterized by red
Crises can be precipitated ... The underlying pathophysiology ... 2) Aplasia - Acute ... of the baseline anaemia ... #Features #Signs
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... count cause hyperviscosity ... - ACS, AKI, acute ... >100k, + lab signs ... : • Pathophysiology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... cytopenias (usually anemia ... risk-stratification • Risks ... transformation to acute
Myasthenia Gravis Overview

Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction.  Ab to
muscles: “myasthenic crises ... test - Cogan sign ... - Peek sign ... Myasthenia Crises ... aspiration and acute
Alexia Without Agraphia
Alexia without agraphia is a disconnection syndrome where patients cannot read but can write.
disconnection syndrome ... the most common cause ... lobe is unable to cross ... Pathophysiology: ... #diagnosis #pathophysiology
Scleroderma Renal Crisis (SRC)

Clinical Presentation of Scleroderma Renal Crisis:
1) Acute kidney injury
2) Abrupt onset of hypertension
3)
: 1) Acute kidney ... microangiopathic hemolytic anemia ... (MAHA) Pathophysiology ... #rheumatology # ... nephrology #diagnosis
Guillain-Barre Syndrome - Summary

Acute AIDP that presents with rapidly progressive flaccid weakness

Epidemiology:
 • 1-2 cases/100,000 per
- Summary Acute ... Epidemiology: • 1-2 cases ... Guillain-Barre Pathophysiology ... - NORMAL CSF WBC ... variants: (1) acute
Posterior Reversible Encephalopathy Syndrome (PRES) Overview

Clinico-Radiological Syndrome, characterized by:
 • Headache
 • Seizures
 • Altered mental
• Hypertensive crisis ... Etiology: • Pathophysiology ... , ADEM, Acute toxic ... the underlying cause ... with AEDs until cause
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... count ↑ PLT • ↑ PBS ... develop leukostasis syndrome ... - infiltrates (anemia ... • Tumor lysis syndrome
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... Lymphocytosis on CBC ... • Neutropenia, anemia ... • Richter’s Syndrome ... ’s lymphoma or acute