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rheumatology management differential treatment ana antinuclear erythematosus latenttb lupus syndrome tb tuberculosis arthritis autoantibodies chronic classification cll igg4 immune inflammatory
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... healthy adults, and should ... , Interstitial Pulmonary ... ANA #patterns #rheumatology ... #diagnosis #differential
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
• Skeletal system ... Tuberculosis Diagnosis ... staining, NAA (PCR ... HIV-infected patients should ... Tuberculosis #TB #Diagnosis
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
• Skeletal system ... Tuberculosis Diagnosis ... staining, NAA (PCR ... HIV-infected patients should ... Tuberculosis #TB #Diagnosis
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... affected joint • Systemic ... double-stranded DNA antibodies ... should be obtained ... #diagnosis #testing
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... activity (when ... clinically suspected, tests ... erythematosus #diagnosis ... table #ANA
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
IgG4-Related Disease ... female, asian • Systemic ... specific laboratory tests ... autoantibodies (antinuclear antibodies ... #phenotypes #workup
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Central nervous system ... : • 10%-15% Pulmonary ... , INC risk PE, Pulmonary ... Nephrogenic DI Hematologic ... muscarinic agonists • Active
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Differential Diagnosis ... La, anti-Jo-1, SCL ... -70, RNP antibodies ... Erythematosus #Diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... progressing GN • New pulmonary ... retinopathy Lab Tests ... C-ANCA) pattern: antibodies ... #rheumatology #
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
rendering the immune system ... adults in the west ... cells can indicate disease ... #workup #oncology ... #hematology
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