8 results
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
- Differential Diagnosis ... and Workup History ... (CVID, WAS), (neurologic ... changes), high MCV anemia ... #hematology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
- Differential Diagnosis ... Drug-associated, PCH ... Defects: Sickle cell anemia ... Laboratory Tests ... #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
• Symptoms of anemia ... anemia • Cold ... Test: Donath-Landsteiner ... test #cold # ... #hematology #diagnosis
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of
Rheumatology Workup ... should be obtained ... the presence of anemia ... (to support a diagnosis ... #diagnosis #testing
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
hallmark for the disease ... value is low, tests ... result in severe anemia ... immune hemolytic anemia ... #Workup #Hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
adults in the west ... cells can indicate disease ... • Neutropenia, anemia ... #workup #oncology ... #hematology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• Heavy Chain disease ... et diutinum Neurologic ... (-) hemolytic anemia ... Paraproteinemias #Hematology ... #Differential #Diagnosis
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
Albumin > 4) Work-up ... gap (>4 g/dL) should ... gastric tumors • Hematology ... #differential #diagnosis ... #hematology