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Acid-Base Disorders - Differential Diagnosis Algorithm
Acidemia (pH < 7.35)
 • Metabolic Acidosis (HCO3 < 24mmol/L) CO2
Acid-Base Disorders ... - Differential Diagnosis ... Respiratory Acidosis (pCO2 ... Respiratory Alkalosis (pCO2 ... #Differential #Diagnosis
Acid Base Compensation - Directions - If all three variables (pH, HCO2, pCO2) move in the
Acid Base Compensation ... variables (pH, HCO2 ... , pCO2) move in ... #Diagnosis #Nephro
PLACO Mnemonic - Approach to Acid-Base Disorders
P - Determine the pH
L - Labs: PCO2 & HCO3
A
- Approach to Acid-Base ... pH L - Labs: PCO2 ... PLACO #AcidBase #Acid ... #Base #diagnosis
Acid Base and Blood Gas Analysis
1. pH - What’s the primary disturbance?
2. pCO2 - What’s the
Acid Base and Blood ... 2. pCO2 - What’s ... the pCO2? ... Medications, Central, ↑ CO2 ... workup #algorithm #diagnosis
Acid Base Disorders Worksheet

Step 1: Gather the necessary data (Na+, CI-, HCO3-, PH, pCO2). Preferably, all
Acid Base Disorders ... CI-, HCO3-, PH, pCO2 ... Step 7: Make the diagnoses ... joshsteinbergMD #Acid ... Disorders #Worksheet #diagnosis
Approach to the A-a Gradient
A-a gradient = PAO2 - PaO2
A-a gradient = [FiO2 x (Patm -
A-a gradient = PAO2 ... - PaO2 A-a gradient ... (Patm - 47) - (PaCO2 ... Level) [150- (PaCO2 ... #differential #diagnosis
Capnography
Measurement of exhaled carbon dioxide can be used to confirm ETT placement, for safer procedural sedation,
- Alveolar CO2 ... • PvCO2 - Mixed ... venous CO2 • ... PaCO2 - Arterial ... waveforms #patterns #diagnosis
Oxygen-Hemoglobin Dissociation Curve

Left Shift (↓ O2 unloading to tissue), Left = Lower:
 • ↓ H+ (↑
+ (↑ pH) • ↓ PCO2 ... tissue): • ↑ H+ (Acid ... ) • ↑ PCO2
What's in a Blood Gas? VBG vs ABG

BOTTOM LINE: VBG is less painful, more easily obtained
very well, and PvCO2 ... #EBM #Diagnosis ... Comparison #PH #PCO2
Arterial Blood Gas (ABG) Analysis - Metabolic + Respiratory Acidosis + Alkalosis

pH ↓ pCO2 ↓ -
Alkalosis pH ↓ pCO2 ... acidosis pH ↑ pCO2 ... alkalosis pH ↑ pCO2 ... alkalosis pH ↓ pCO2 ... Interpretation #AcidBase #Diagnosis