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PLACO Mnemonic - Approach to Acid-Base Disorders
P - Determine the pH
L - Labs: PCO2 & HCO3
A
Approach to Acid-Base ... pH L - Labs: PCO2 ... AcidBase #Acid #Base
Acid-Base Disorders - Differential Diagnosis Algorithm
Acidemia (pH < 7.35)
 • Metabolic Acidosis (HCO3 < 24mmol/L) CO2
Acid-Base Disorders ... Respiratory Acidosis (pCO2 ... Respiratory Alkalosis (pCO2
Acid Base Disorders Worksheet

Step 1: Gather the necessary data (Na+, CI-, HCO3-, PH, pCO2). Preferably, all
Acid Base Disorders ... CI-, HCO3-, PH, pCO2 ... 3: Look at the pCO2 ... . 3a: If pCO2 ... joshsteinbergMD #Acid #Base
Acid-Base Disorders - Expected Compensation Equations

Metabolic Acidosis:
 • pCO2 = 1.5 x HCO3 + 8 ±
Acid-Base Disorders ... Acidosis: • pCO2 ... ∆ HCO3 ↓ 1 → ∆ pCO2 ... Alkalosis: • pCO2 ... ↓ 4 #Acid #Base
Acid Base Compensation - Directions - If all three variables (pH, HCO2, pCO2) move in the
Acid Base Compensation ... variables (pH, HCO2, pCO2
Acid Base and Blood Gas Analysis
1. pH - What’s the primary disturbance?
2. pCO2 - What’s the
Acid Base and Blood ... 2. pCO2 - What’s ... the pCO2?
Blood Gas (ABG) Interpretation and Acid-Base Pathology
1- Does the patient have an acidosis or an alkalosis?
Interpretation and Acid-Base ... Look at the pCO2 ... Metabolic Equal (If pCO2 ... the change in pCO2 ... calculate the expected pCO2
Approach to Acid Base Disorders - Evaluation and Differential Diagnosis
1) Start with the Anion Gap (AG).
2)
Approach to Acid Base ... than expected based ... Generally, for acid/base ... and ~5 mmHg to pCO2 ... EmmGeezee #Acid #Base
#ICUCard
RENAL
GFR
90-131
mL/min
((140-age)*Wt)/(72*Cr)
Glomerular Filtration Rate (Cockcroft)
CI Cr
90-131
mL/min
(CrU * volume)/CrS
Creatinine Clearance
FENa
0.0-1.0
%
((U/P Na)/(U/P Cr))*100
Fractional Excretion of Na+
Na req
mEq
(125-Na)*0.6*Wt
Required Sodium
FE Urea
Osmolar Gap ACID-BASE ... pCO2 = 1.5 (HCO3 ... ТНСО3 → TPCO2 pCO2 ... pk + log (HCO3/(PCO2 ... PaCO2)/HCO3 Acid base
Acid Base Disorders - Blood Gas Interpretation

Steps for Blood Gas Interpretation: 
1. Acidemia or Alkalemia? 
2.
Acid Base Disorders ... Metabolic: pH pCO2 ... bloodgas #Acid #Base